Dr Tom Mules
Clinical Consultant - Mules Research Group
Dr Tom Mules is a physician specialising in gastroenterology and hepatology, and lecturer at the University of Otago School of Medicine. His research interests include the role of intestinal barrier dysfunction in disease, hookworm therapy, Helicobacter pylori and the psychosocial impact of inflammatory bowel disease.
Tom wrote his PhD thesis on the relationship between gut health and metabolic disease, and whether we can design intervention strategies to improve the function of the intestinal barrier to improve health outcomes.
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Publications
2024
Noble SL, Mules TC, Le Gros G, Inns S (2024). The immunoregulatory potential of eosinophil subsets. Immunol Cell Biol. 102(9):775-786.
Noble SL, Vacca F, Hilligan KL, Mules TC, Le Gros G, Inns S (2024). Helminth infection induces a distinct subset of CD101hi lung tissue-infiltrating eosinophils that are differentially regulated by type 2 cytokines. Immunol Cell Biol. 102(8):734-746.
Mules TC, Tang JS, Vacca F, Yumnam B, Schmidt A, Lavender B, Maclean K, Noble SL, Waugh C, van Ginkel R, Camberis M, Le Gros G, Inns S (2024). Modulation of intestinal epithelial permeability by chronic small intestinal helminth infections. Immunol Cell Biol. 102(5):396-406
2023
Mules TC, Inns S, Le Gros G (2023). Helminths' therapeutic potential to treat intestinal barrier dysfunction. Allergy. 78(11):2892-2905
Mules TC, Lavender B, Maclean K, Vacca F, Noble SL, Yumnam B, Te Kawa T, Cait A, Tang J, O'Sullivan D, Gasser O, Stanley J, Le Gros G, Camberis M, Inns S (2023). Controlled Hookworm Infection for Medication-free Maintenance in Patients with Ulcerative Colitis: A Pilot, Double-blind, Randomized Control Trial. Inflamm Bowel Dis. 2023 Jun 15