Research outputs from the Malaghan Institute regularly feature in high-impact scientific journals and publications.
Publications
2024
McGregor R, Paterson A, Lavender B, Hooker C, Frampton C, Wiig K, Le Gros G, Ussher JE, Brewerton M, Moreland NJ (2024). The SARS-CoV-2 neutralising antibody profile of New Zealand adults in 2023: Impact of vaccination and infection. Vaccine. 42(26):126482.
Vodicka P, Vodenkova S, Danesova N, Vodickova L, Zobalova R, Tomasova K, Boukalova S, Berridge MV, Neuzil J (2024). Mitochondrial DNA damage, repair, and replacement in cancer. Trends Cancer. S2405-8033(24)00212-7.
Vacca F, Mules TC, Camberis M, Lavender B, Noble SL, Cait A, Maclean K, Mamum J, Yumnam B, Te Kawa T, Ferrer-Font L, Tang JS, Gasser O, Le Gros G, Inns S (2024). Controlled infection with cryopreserved human hookworm induces CTLA-4 expression on Tregs and upregulates tryptophan metabolism. Gut Microbes. 16(1):2416517.
Ronchese F, Webb GR, Ochiai S, Lamiable O, Brewerton M (2024). How type-2 dendritic cells induce Th2 differentiation: Instruction, repression, or fostering T cell-T cell communication? Allergy. 2024 Sep 26.
Noble SL, Mules TC, Le Gros G, Inns S (2024). The immunoregulatory potential of eosinophil subsets. Immunol Cell Biol. 102(9):775-786.
Samaratunga H, Delahunt B, Olsson M, Aly M, Egevad L, Yaxley J (2024). Benign prostatic hyperplasia and insignificant prostate cancer with very high levels of serum prostate specific antigen. Pathology. 2024 Aug 12:S0031-3025(24)00189-2.
Wall CR, Roy NC, Mullaney JA, McNabb WC, Gasser O, Fraser K, Altermann E, Young W, Cooney J, Lawrence R, Jiang Y, Galland BC, Fu X, Tonkie JN, Mahawar N, Lovell AL (2024). Nourishing the Infant Gut Microbiome to Support Immune Health: Protocol of SUN (Seeding Through Feeding) Randomized Controlled Trial. JMIR Res Protoc. 13:e56772.
Wang H, Barry K, Zaini A, Coakley G, Moyat M, Daunt CP, Wickramasinghe LC, Azzoni R, Chatzis R, Yumnam B, Camberis M, Le Gros G, Perdijk O, Foong JPP, Bornstein JC, Marsland BJ, Harris NL (2024). Helminth infection driven gastrointestinal hypermotility is independent of eosinophils and mediated by alterations in smooth muscle instead of enteric neurons. PLoS Pathog. 20(8):e1011766.
Brown JR, Eichhorst B, Hillmen P, Jurczak W, Kaźmierczak M, Lamanna N, O'Brien SM, Tam CS, Qiu L, Zhou K, Simkovic M, Mayer J, Gillespie-Twardy A, Ferrajoli A, Ganly PS, Weinkove R, Grosicki S, Mital A, Robak T, Osterborg A, Yimer HA, Salmi T, Wang MD, Fu L, Li J, Wu K, Cohen A, Shadman M (2024). Plain language summary of zanubrutinib or ibrutinib in chronic lymphocytic leukemia that is resistant to treatment or has come back after treatment. Future Oncol. 20(12):717-726.
Logan JM, Martini C, Sorvina A, Johnson IRD, Brooks RD, Caruso MC, Huzzell C, Moore CR, Karageorgos L, Butler LM, Tewari P, Prabhakaran S, Hickey SM, Klebe S, Samaratunga H, Delahunt B, Moretti K, O'Leary JJ, Brooks DA, Ung BS (2024). Reinterpretation of prostate cancer pathology by Appl1, Sortilin and Syndecan-1 biomarkers. Sci Data. 11(1):852.
Asosingh K, Bayiyana A, Black MC, Chakraborty U, Clemente MJ, Graham AC, Gregory MD, Hogg KG, Van Isterdael G, Liu C, Martínez L, Petersen CC, Porat Z, Price KM, Prickett LB, Rieger AM, Roe CE, Smit E (2024). Best practices for user consultation in flow cytometry shared resource laboratories. Cytometry A. 105(9):704-712.
Blud D, Rubio-Reyes P, Perret R, Weinkove R (2024). Tuning CAR T-cell therapies for efficacy and reduced toxicity. Semin Hematol. 61(5):333-344.
Strumberg D, Kilfoyle A, Manzoor BS, Jawaid D, Emechebe N, Devine J, Boyer M, Runkel ED, Eichhorst B, Stilgenbauer S, Jiang Y, Hallek MJ, Fischer K (2024). Venetoclax-Obinutuzumab for previously untreated chronic lymphocytic leukemia: 6-year results of the phase 3 CLL14 study. Blood. 144(18):1924-1935.
Pankhurst TE, Linterman MA (2024). Highlight of 2023: Advances in germinal centers. Immunol Cell Biol. 102(6):463-466.
Noble SL, Vacca F, Hilligan KL, Mules TC, Le Gros G, Inns S (2024). Helminth infection induces a distinct subset of CD101hi lung tissue-infiltrating eosinophils that are differentially regulated by type 2 cytokines. Immunol Cell Biol. 102(8):734-746.
Lee JE, Kim M, Ochiai S, Kim SH, Yeo H, Bok J, Kim J, Park M, Kim D, Lamiable O, Lee M, Kim MJ, Kim HY, Ronchese F, Kwon SW, Lee H, Kim TG, Chung Y (2024). Tonic type 2 immunity is a critical tissue checkpoint controlling autoimmunity in the skin. Cell Rep. 43(7):114364
van de Wetering R, Bibi R, Biggerstaff A, Hong S, Pengelly B, Prisinzano TE, La Flamme AC, Kivell BM (2024). Nalfurafine promotes myelination in vitro and facilitates recovery from cuprizone + rapamycin-induced demyelination in mice. Glia. 72(10):1801-1820.
Lasica M, Anderson MA, Boussioutas A, Gregory GP, Hamad N, Manos K, McKelvie P, Ng M, Campbell B, Palfreyman E, Salvaris R, Weinkove R, Wight J, Opat S, Tam C (2024). Marginal zone lymphomas: a consensus practice statement from the Australasian Lymphoma Alliance. Intern Med J. 54(6):1017-1030
MacPhail A, Dendle C, Slavin M, Weinkove R, Bailey M, Pilcher D, McQuilten Z (2024). Neutropenic Sepsis in the Intensive Care Unit: Differences in Clinical Profile and Outcomes According to the Cause of Neutropenia. Open Forum Infect Dis. 11(6):ofae289
Pankhurst TE, Montgomerie I, Marshall A, Draper SL, Bilbrough T, Button KR, Palmer OR, Hermans IF, Painter GF, Connor LM, Compton BJ (2024). A Glycolipid-Peptide-Hapten Tricomponent Conjugate Vaccine Generates Durable Antihapten Antibody Responses in Mice. ACS Chem Biol. 19(6):1366-1375
MacPhail A, Dendle C, Slavin M, Weinkove R, Bailey M, Pilcher D, McQuilten Z (2024). Sepsis mortality among patients with haematological malignancy admitted to intensive care 2000-2022: a binational cohort study. Crit Care. 28(1):148
Ferrer-Font L, Burn OK, Mayer JU, Price KM (2024). Immunophenotyping challenging tissue types using high-dimensional full spectrum flow cytometry. Methods Cell Biol. 186:51-90
Mooney AH, Draper SL, Burn OK, Anderson RJ, Compton BJ, Tang C, Farrand KJ, Di Lucia P, Ravà M, Fumagalli V, Giustini L, Bono E, Godfrey DI, Heath WR, Yuan W, Chisari FV, Guidotti LG, Iannacone M, Sidney J, Sette A, Gulab SA, Painter GF, Hermans IF (2024). Preclinical evaluation of therapeutic vaccines for chronic hepatitis B that stimulate antiviral activities of T cells and NKT cells. JHEP Rep. 6(5):101038.
Mules TC, Tang JS, Vacca F, Yumnam B, Schmidt A, Lavender B, Maclean K, Noble SL, Waugh C, van Ginkel R, Camberis M, Le Gros G, Inns S (2024). Modulation of intestinal epithelial permeability by chronic small intestinal helminth infections. Immunol Cell Biol. 102(5):396-406
Torres SV, Man K, Elmzzahi T, Malko D, Chisanga D, Liao Y, Prout M, Abbott CA, Tang A, Wu J, Becker M, Mason T, Haynes V, Tsui C, Shakiba MH, Hamada D, Britt K, Groom JR, McColl SR, Shi W, Watt MJ, Le Gros G, Pal B, Beyer M, Vasanthakumar A, Kallies A (2024). Two regulatory T cell populations in the visceral adipose tissue shape systemic metabolism. Nat Immunol. 25(3):496-511
Hornsteiner F, Vierthaler J, Strandt H, Resag A, Fu Z, Ausserhofer M, Tripp CH, Dieckmann S, Kanduth M, Farrand K, Bregar S, Nemati N, Hermann-Kleiter N, Seretis A, Morla S, Mullins D, Finotello F, Trajanoski Z, Wollmann G, Ronchese F, Schmitz M, Hermans IF, Stoitzner P (2024). Tumor-targeted therapy with BRAF-inhibitor recruits activated dendritic cells to promote tumor immunity in melanoma. J Immunother Cancer. 12(4):e008606
McQuilten ZK, Weinkove R, Thao LTP, Crispin P, Degelia A, Dendle C, Gilbertson M, Johnston A, Keegan A, Pepperell D, Pullon H, Reynolds J, van Tonder T, Trotman J, Waters N, Wellard C, Weston H, Morrissey CO, Wood EM (2024). Immunoglobulin replacement vs prophylactic antibiotics for hypogammaglobulinemia secondary to hematological malignancy. Blood Adv. 8(7):1787-1795
Baker PJ, Bohrer AC, Castro E, Amaral EP, Snow-Smith M, Torres-Juárez F, Gould ST, Queiroz ATL, Fukutani ER, Jordan CM, Khillan JS, Cho K, Barber DL, Andrade BB, Johnson RF, Hilligan KL, Mayer-Barber KD (2024). The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication. bioRxiv [Preprint]. 2024.03.27.586885
Ferrer-Font L, Small SJ, Hyde E, Pilkington KR, Price KM (2024). Panel Design and Optimization for Full Spectrum Flow Cytometry. Methods Mol Biol. 2779:99-124
Burn OK, Mair F, Ferrer-Font L (2024). Combinatorial antibody titrations for high-parameter flow cytometry. Cytometry A. 105(5):388-393
Kyle RL, Prout M, Le Gros G, Robinson MJ (2024). STAT6 tunes maximum T cell IL-4 production from stochastically regulated Il4 alleles. Immunol Cell Biol. 102(3):194-211
Cait A, Woods K, Naidoo K, Gell K, Schmidt A, Jackson R, Grooby A, O'Sullivan D, Gasser O (2024). Tissue-specific contribution of mucosal-associated invariant T cells to allergic airway inflammation. Allergy. 2024 Jan 25
Fyfe R, Anstis O, Kapadia K, Jordan M, Sword DO, Weinkove R (2024). Experiences and perspectives on chimeric antigen receptor (CAR) T-cell therapy among recipients, carers and referrers (RE-TELL): a qualitative study to inform CAR T-cell service design. BMJ Open. 14(1):e071112
2023
Campbell A, Teh B, Mulligan S, Ross DM, Weinkove R, Gilroy N, Gangatharan S, Prince HM, Szer J, Trotman J, Lane S, Dickinson M, Quach H, Enjeti AK, Ku M, Gregory G, Hapgood G, Ho PJ, Cochrane T, Cheah C, Greenwood M, Latimer M, Berkahn L, Wight J, Armytage T, Diamond P, Tam CS, Hamad N (2023). Australia and New Zealand consensus position statement: use of COVID-19 therapeutics in patients with haematological malignancies. Intern Med J. 2023 Dec 25
Buckstein R, Callum J, Prica A, Bowen D, Wells RA, Leber B, Heddle N, Chodirker L, Cheung M, Mozessohn L, Yee K, Gallagher J, Parmentier A, Jamula E, McQuilten Z, Wood EM, Weinkov R, Zhang L, Mamedov A, Stanworth SJ, Lin Y (2023). Red cell transfusion thresholds in outpatients with myelodysplastic syndromes: Combined results from two randomized controlled feasibility studies. Am J Hematol. 2023 Dec 21
Mo A, Weinkove R, Wood EM, Shortt J, Johnston A, McQuilten ZK; Australasian Leukaemia and Lymphoma Group Supportive Care Scientific Working Party (2023). Use of platelet transfusions and tranexamic acid in patients with myelodysplastic syndromes: A clinical practice survey. Eur J Haematol. 2023 Dec 20
Robichon K, Bibi R, Kiernan M, Denny L, Prisinzano TE, Kivell BM, La Flamme AC (2023). Enhanced and complementary benefits of a nalfurafine and fingolimod combination to treat immune-driven demyelination. Clin Transl Immunology. 12(12):e1480
Brown JR, Eichhorst B, Hillmen P, Jurczak W, Kaźmierczak M, Lamanna N, O'Brien SM, Tam CS, Qiu L, Zhou K, Simkovic M, Mayer J, Gillespie-Twardy A, Ferrajoli A, Ganly PS, Weinkove R, Grosicki S, Mital A, Robak T, Osterborg A, Yimer HA, Salmi T, Wang MD, Fu L, Li J, Wu K, Cohen A, Shadman M (2023). Plain language summary of zanubrutinib or ibrutinib in chronic lymphocytic leukemia that is resistant to treatment or has come back after treatment. Future Oncol. 2023 Dec 13
Hilligan KL, Namasivayam S, Clancy CS, Baker PJ, Old SI, Peluf V, Amaral EP, Oland SD, O'Mard D, Laux J, Cohen M, Garza NL, Lafont BAP, Johnson RF, Feng CG, Jankovic D, Lamiable O, Mayer-Barber KD, Sher A (2023). Bacterial-induced or passively administered interferon gamma conditions the lung for early control of SARS-CoV-2. Nat Commun. 14(1):8229
Kirman JR, Weinkove R, Borger JG (2023). Immunology across two islands: understanding the research landscape of Aotearoa (New Zealand). Immunol Cell Biol. 2023 Nov 3
Peck T, Davis C, Lenihan-Geels G, Griffiths M, Spijkers-Shaw S, Zubkova OV, La Flamme AC (2023). The novel HS-mimetic, Tet-29, regulates immune cell trafficking across barriers of the CNS during inflammation. J Neuroinflammation. 20(1):251
Tang JS, Stephens R, Li Y, Cait A, Gell K, Faulkner S, Grooby A, Herst PM, O'Sullivan D, Gasser O (2023). Polyphenol and glucosinolate-derived AhR modulators regulate GPR15 expression on human CD4+ T cells. J Nutr Biochem. 122:109456
McKenzie RE, Minnell JJ, Ganley M, Painter GF, Draper SL (2023). mRNA Synthesis and Encapsulation in Ionizable Lipid Nanoparticles. Curr Protoc. 3(9):e898
Hilligan KL, Namasivayam S and Sher A (2023) BCG mediated protection of the lung against experimental SARS-CoV-2 infection. Front. Immunol. 14:1232764
Copedo JS, Webb SC, Ragg NLC, Ericson JA, Venter L, Schmidt AJ, Delorme NJ, Alfaro AC (2023). Histopathological changes in the greenshell mussel, Perna canaliculus, in response to chronic thermal stress. J Therm Biol. 117:103699
Cochrane T, Enrico A, Gomez-Almaguer D, Hadjiev E, Lech-Maranda E, Masszi T, Nikitin E, Robak T, Weinkove R, Wu SJ, Manzoor BS, Busman T, Pai M, Komlosi V, Anderson MA (2023). Updated quality of life data from the phase 3b VENICE II trial: patients with relapsed or refractory chronic lymphocytic leukemia receiving venetoclax monotherapy. Leuk Lymphoma. 2023 Aug 25:1-4
Oyesola OO, Hilligan KL, Namasivayam S, Howard N, Clancy CS, Zhao M, Oland SD, Kiwanuka KN, Garza NL, Lafont BAP, Johnson RF, Mayer-Barber KD, Sher A, Loke P (2023). Exposure to lung-migrating helminth protects against murine SARS-CoV-2 infection through macrophage-dependent T cell activation. Sci Immunol. 8(86):eadf816
Wiles AK, Mehta S, Millier M, Woolley AG, Li K, Parker K, Kazantseva M, Wilson M, Young K, Bowie S, Ray S, Slatter TL, Stamp LK, Hessian PA, Braithwaite AW. Activated CD90/Thy-1 fibroblasts co-express the Δ133p53β isoform and are associated with highly inflamed rheumatoid arthritis. Arthritis Res Ther. 25(1):62
Samaratunga H, Egevad L, Yaxley JW, Johannsen S, Le Fevre IK, Perry-Keene JL, Gianduzzo T, Chabert C, Coughlin G, Parkinson R, Kua B, Yaxley W, Delahunt B. Clinicopathologic Significance of Anterior Prostate Cancer: Comparison With Posterior Prostate Cancer in the Era of Multiparametric Magnetic Resonance Imaging. Am J Surg Pathol. 47(6):701-708
Buckle I, Johnson A, Rojas IL, Weinert V, Sester DP, Radford K, Guillerey C. High dimensional analysis reveals distinct NK cell subsets but conserved response to stimulation in umbilical cord blood and adult peripheral blood. Eur J Immunol. 53(6):e2250118
Cooney TR, Farrand K, Draper SL, Anderson RJ, Rendle PM, Hermans IF, Compton BJ, Painter GF. Synthesis and Biological Evaluation of Peptide-Adjuvant Conjugate Vaccines with Increasing Antigen Content. Bioconjug Chem. 2023 Apr 6
Pankhurst TE, Buick KH, Lange JL, Marshall AJ, Button KR, Palmer OR, Farrand KJ, Montgomerie I, Bird TW, Mason NC, Kuang J, Compton BJ, Comoletti D, Salio M, Cerundolo V, Quiñones-Mateu ME, Painter GF, Hermans IF, Connor LM (2023). MAIT cells activate dendritic cells to promote TFH cell differentiation and induce humoral immunity. Cell Rep. 42(4):112310
Yuen HLA, Weinkove R, Ullman A, Marsh N, Rickard CM, Chunilal S, McQuilten Z (2023). Central venous access device practice across haematology and oncology centres in Australia and New Zealand: a cross-sectional survey. Intern Med J. 53(3):426-43
Dasyam N, Sharples KJ, Barrow C, Huang Y, Bauer E, Mester B, Wood CE, Authier-Hall A, Dzhelali M, Ostapowicz T, Kumar R, Lowe J, Maxwell A, Burn OK, Williams GM, Carley SE, Caygill G, Jones J, Chan STS, Hinder VA, Macapagal J, McCusker M, Weinkove R, Brimble MA, Painter GF, Findlay MP, Dunbar PR, Gasser O, Hermans IF (2023). A randomised controlled trial of long NY-ESO-1 peptide-pulsed autologous dendritic cells with or without alpha-galactosylceramide in high-risk melanoma. Cancer Immunol Immunother. 2023 Mar 7
Montgomerie I, Bird TW, Palmer OR, Mason NC, Pankhurst TE, Lawley B, Hernández LC, Harfoot R, Authier-Hall A, Anderson DE, Hilligan KL, Buick KH, Mbenza NM, Mittelstädt G, Maxwell S, Sinha S, Kuang J, Subbarao K, Parker EJ, Sher A, Hermans IF, Ussher JE, Quiñones-Mateu ME, Comoletti D, Connor LM; On behalf theVAANZ Group (2023). Incorporation of SARS-CoV-2 spike NTD to RBD Protein Vaccine Improves Immunity Against Viral Variants. iScience. 26(4):106256
Varma M, Delahunt B, Cheng L, Chetty R, Compérat E, Deshpande V, Egevad L, van der Kwast TH, Lopez-Beltran A, McCluggage WG (2023). Tumour grading: communication is the key. J Clin Pathol. jcp-2023-208824
Dong LF, Rohlena J, Zobalova R, Nahacka Z, Rodriguez AM, Berridge MV, Neuzil J (2023). Mitochondria on the move: Horizontal mitochondrial transfer in disease and health. J Cell Biol. 222(3):e202211044
Ferrer-Font L, Kraker G, Hally KE, Price KM (2023). Ensuring Full Spectrum Flow Cytometry Data Quality for High-Dimensional Data Analysis. Curr Protoc. 3(2):e657
Ferrer-Font L, Schmidt A, Ronchese F, Price KM (2022). A guideline for the appropriate recognition of shared resource laboratories in publication. Cytometry A. 103(3):193-197
2022
Brown JR, Eichhorst B, Hillmen P, Jurczak W, Kaźmierczak M, Lamanna N, O'Brien SM, Tam CS, Qiu L, Zhou K, Simkovic M, Mayer J, Gillespie-Twardy A, Ferrajoli A, Ganly PS, Weinkove R, Grosicki S, Mital A, Robak T, Osterborg A, Yimer HA, Salmi T, Wang MD, Fu L, Li J, Wu K, Cohen A, Shadman M (2022). Zanubrutinib or Ibrutinib in Relapsed or Refractory Chronic Lymphocytic Leukemia. N Engl J Med. 388(4):319-332
Hillmen P, Eichhorst B, Brown JR, Lamanna N, O'Brien SM, Tam CS, Qiu L, Kazmierczak M, Zhou K, Šimkovič M, Mayer J, Gillespie-Twardy A, Shadman M, Ferrajoli A, Ganly PS, Weinkove R, Grosicki S, Mital A, Robak T, Österborg A, Yimer HA, Salmi T, Ji M, Yecies J, Idoine A, Wu K, Huang J, Jurczak W (2022). Zanubrutinib Versus Ibrutinib in Relapsed/Refractory Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma: Interim Analysis of a Randomized Phase III Trial. J Clin Oncol. 41(5):1035-1045
Mulligan SP, Opat S, Cheah CY, Kuss B, Hertzberg M, Marlton P, Poplar S, Puig A, McGeachie M, Weinkove R, Tam CS (2022). Real-world experience of Australian and New Zealand patients with chronic lymphocytic leukemia and mantle cell lymphoma accessing ibrutinib through a Named Patient Program. Leuk Lymphoma. 2022 Nov 24:1-7
Hillmen P, Eichhorst B, Brown JR, Lamanna N, O'Brien SM, Tam CS, Qiu L, Kazmierczak M, Zhou K, Šimkovič M, Mayer J, Gillespie-Twardy A, Shadman M, Ferrajoli A, Ganly PS, Weinkove R, Grosicki S, Mital A, Robak T, Österborg A, Yimer HA, Salmi T, Ji M, Yecies J, Idoine A, Wu K, Huang J, Jurczak W (2022). Zanubrutinib Versus Ibrutinib in Relapsed/Refractory Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma: Interim Analysis of a Randomized Phase III Trial. J Clin Oncol. 2022 Nov 17
Perram J, Purtill D, Bajel A, Butler J, O'Brien T, The B, Gilroy N, Ho PJ, Doocey R, Hills T, Perera T, Douglas G, Ramachadran S, Chee L, Trotman J, Weinkove R, Keogh S, Fraser C, Cochrane T, Watson AM, Diamond P, Latimer M, Irving I, Blyth E, Cheah C, Cole T, Milliken S, Yang H, Greenwood M, Bardy P, Kennedy G, Larsen S, Conyers R, Hamad N (2022). ANZTCT Position Statement: COVID-19 Management in Haematopoietic Stem Cell Transplant and Chimeric Antigen Receptor T cell Patients. Intern Med J. 2022 Nov 13
Munoz-Erazo L, Shinko D, Schmidt AJ, Price KM (2022). Implementing High Dimensional Reduction Analysis on Histocytometric Data. Curr Protoc. 2(11):e586
Qin L, Cui Y, Yuan T, Chen D, Zhao R, Li S, Jiang Z, Wu Q, Long Y, Wang S, Tang Z, Pan H, Li X, Wei W, Yang J, Luo X, Zhang Z, Tang Q, Liu P, Weinkove R, Yao Y, Qin D, Thiery JP, Li P (2022). Co-expression of a PD-L1-specific chimeric switch receptor augments the efficacy and persistence of CAR T cells via the CD70-CD27 axis. Nat Commun. 13(1):6051
Chandler J, Prout M, Old S, Morgan C, Ronchese F, Benoist C, Le Gros G (2022). BCL6 deletion in CD4 T cells does not affect Th2 effector mediated immunity in the skin. Immunol Cell Biol. 2022 Sep 30
Brown JR, Hillmen P, Eichhorst B, Lamanna N, O'Brien S, Tam CS, Qiu L, Kazmierczak M, Zhou K, Šimkovič M, Mayer J, Gillespie-Twardy A, Shadman M, Ferrajoli A, Ganly PS, Weinkove R, Salmi T, Wu K, Novotny W, Jurczak W (2022). CLL-115 First Interim Analysis of ALPINE Study: Results of a Phase 3 Randomized Study of Zanubrutinib vs Ibrutinib in Patients With Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL). Clin Lymphoma Myeloma Leuk. 22 Suppl 2:S266
van der Woude H, Hally KE, Currie MJ, Gasser O, Henry CE (2022). Importance of the endometrial immune environment in endometrial cancer and associated therapies. Front Oncol. 12:975201
Al Abadey A, Connor B, Flamme AC, Robichon K (2022). Clozapine reduces chemokine-mediated migration of lymphocytes by targeting NF-κB and AKT phosphorylation. Cell Signal. 99:110449
Tang JS, Cait A, White RM, Arabshahi HJ, O’Sullivan D and Gasser O (2022). MR1-dependence of unmetabolized folic acid side-effects. Front. Immunol. 13:946713
Chai KL, Wong JWK, Weinkove R, Keegan A, Crispin PJ, Stanworth SJ, Morrissey O, Wood EM, McQuilten Z (2022). Interventions to reduce infections in patients with hematological malignancies: a systematic review and meta-analysis. Blood Adv. 2022 Jul 26
Priddy FH, Williams M, Carson S, Lavender B, Mathieson J, Frampton C, Moreland NJ, McGregor R, Williams G, Brewerton M, Gell K, Ussher J, Le Gros G (2022). Immunogenicity of BNT162b2 COVID-19 vaccine in New Zealand adults. Vaccine. 40(34):5050-5059
Farrand K, Holz LE, Ferrer-Font L, Wilson MD, Ganley M, Minnell JJ, Tang CW, Painter GF, Heath WR, Hermans IF, Burn OK (2022). Using Full-Spectrum Flow Cytometry to Phenotype Memory T and NKT Cell Subsets with Optimized Tissue-Specific Preparation Protocols. Curr Protoc. 2(7):e482.
Burn OK, Farrand K, Pritchard T, Draper S, Tang CW, Mooney AH, Schmidt AJ, Yang SH, Williams GM, Brimble MA, Kandasamy M, Marshall AJ, Clarke K, Painter GF, Hermans IF, Weinkove R (2022). Glycolipid-peptide conjugate vaccines elicit CD8+ T-cell responses and prevent breast cancer metastasis. Clin Transl Immunology. 11(7):e1401
Prasit KK, Ferrer-Font L, Burn OK, Anderson RJ, Compton BJ, Schmidt AJ, Mayer JU, Chen CJ, Dasyam N, Ritchie DS, Godfrey DI, Mattarollo SR, Dundar PR, Painter GF, Hermans IF (2022). Intratumoural administration of an NKT cell agonist with CpG promotes NKT cell infiltration associated with an enhanced antitumour response and abscopal effect. Oncoimmunology. 11(1):2081009
Cait A, Wedel A, Arntz JL, Duinkerken J, Datye S, Cait J, Alhasan MM, Conrad ML (2022). Prenatal antibiotic exposure, asthma and the atopic march: A systematic review and meta-analysis. Allergy. 2022 Jun 11
Vacca F, Le Gros G (2022). Tissue-specific immunity in helminth infections. Mucosal Immunol. 2022 Jun 9:1–12
Meijlink MA, Chua YC, Chan STS, Anderson RJ, Rosenberg MW, Cozijnsen A, Mollard V, McFadden GI, Draper SL, Holz LE, Hermans IF, Heath WR, Painter GF, Compton BJ (2022). 6″-Modifed α-GalCer-peptide conjugate vaccine candidates protect against liver-stage malaria. RSC Chem Biol. 3(5):551-560
Lamiable O, Brewerton M, Ronchese F (2022). IL-13 in dermal type-2 dendritic cell specialization: from function to therapeutic targeting. Eur J Immunol. 52(7):1047-1057
Munoz-Erazo L, Schmidt AJ, Shinko D, Eccles DA, Price KM (2022). Creation of High-Dimensional Reduction Analysis-Compatible Histocytometry Files from Images of Densely-Packed Cells and/or Variable Stain Intensity. Curr Protoc. 2(5):e441
Lovell AL, Eriksen H, McKeen S, Mullaney J, Young W, Fraser K, Altermann E, Gasser O, Kussmann M, Roy NC, McNabb WC, Wall CR (2022). "Nourish to Flourish": complementary feeding for a healthy infant gut microbiome-a non-randomised pilot feasibility study. Pilot Feasibility Stud. 8(1):103
Lopez R, Li B, Keren-Shaul H, Boyeau P, Kedmi M, Pilzer D, Jelinski A, Yofe I, David E, Wagner A, Ergen C, Addadi Y, Golani O, Ronchese F, Jordan MI, Amit I, Yosef N (2022). DestVI identifies continuums of cell types in spatial transcriptomics data. Nat Biotechnol. 40(9):1360-1369
Herst PM, Carson GM, Eccles DA, Berridge MV (2022). Bioenergetic and Metabolic Adaptation in Tumor Progression and Metastasis. Front Oncol. 12:857686. 2022
Jiang Z, Qin L, Tang Y, Liao R, Shi J, He B, Li S, Zheng D, Cui Y, Wu Q, Long Y, Yao Y, Wei Z, Hong Q, Wu Y, Mai Y, Gou S, Li X, Weinkove R, Norton S, Luo W, Feng W, Zhou H, Liu Q, Chen J, Lai L, Chen X, Pei D, Graf T, Liu X, Li Y, Liu P, Zhang Z, Li P (2022). Human induced-T-to-natural killer cells have potent anti-tumour activities. Biomark Res. 10(1):13
Woods K, Cait A, Gell K, Naidoo K, Brown C, Carpenter E, Gasser O (2022). Goat milk-derived lipids restrain NKT cell-dependent eosinophilic inflammation in a murine model of atopic dermatitis. J Invest Dermatol. 14:S0022-202X(22)00200-7
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2021
Paton KF, Robichon K, Templeton N, Denny L, Al Abadey A, Luo D, Prisinzano TE, La Flamme AC, Kivell BM (2021). The Salvinorin Analogue, Ethoxymethyl Ether Salvinorin B, Promotes Remyelination in Preclinical Models of Multiple Sclerosis. Front Neurol. 12:782190
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Naidoo K, Woods K, Pellefigues C, Cait A, O'Sullivan D, Gell K, Marshall AJ, Anderson RJ, Li Y, Schmidt A, Prasit K, Mayer JU, Gestin A, Hermans IF, Painter G, Jacobsen EA, Gasser O (2021). MR1-dependent immune surveillance of the skin contributes to pathogenesis and is a photobiological target of UV light therapy in a mouse model of atopic dermatitis. Allergy. 76(10):3155-3170
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Ezrova Z, Nahacka Z, Stursa J, Werner L, Vlcak E, Kralova Viziova P, Berridge MV, Sedlacek R, Zobalova R, Rohlena J, Boukalova S, Neuzil J (2021). SMAD4 loss limits the vulnerability of pancreatic cancer cells to complex I inhibition via promotion of mitophagy. Oncogene. 40(14):2539-2552
La Flamme AC, Abernethy D, Sim D, Goode L, Lockhart M, Bourke D, Milner I, Garrill TM, Joshi P, Watson E, Smyth D, Lance S, Connor B (2021). Safety and acceptability of clozapine and risperidone in progressive multiple sclerosis: a phase I, randomised, blinded, placebo-controlled trial. BMJ Neurol Open. 2(1):e000060
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Denny L, Al Abadey A, Robichon K, Templeton N, Prisinzano TE, Kivell BM, La Flamme AC (2021). Nalfurafine reduces neuroinflammation and drives remyelination in models of CNS demyelinating disease. Clin Transl Immunology. 10(1):e1234
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2020
Evaluation of Biased and Balanced Salvinorin A Analogs in Preclinical Models of Pain. Front Neurosci. 14:765
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Jayasinghe TN, Vatanen T, Chiavaroli V, Jayan S, McKenzie EJ, Adriaenssens E, Derraik JGB, Ekblad C, Schierding W, Battin MR, Thorstensen EB, Cameron-Smith D, Forbes-Blom E, Hofman PL, Roy NC, Tannock GW, Vickers MH, Cutfield WS, O'Sullivan JM (2020). Differences in Compositions of Gut Bacterial Populations and Bacteriophages in 5-11 Year-Olds Born Preterm Compared to Full Term. Front Cell Infect Microbiol. 10:276
Holz LE, Chua YC, de Menezes MN, Anderson RJ, Draper SL, Compton BJ, Chan STS, Mathew J, Li J, Kedzierski L, Wang Z, Beattie L, Enders MH, Ghilas S, May R, Steiner TM, Lange J, Fernandez-Ruiz D, Valencia-Hernandez AM, Osmond TL, Farrand KJ, Seneviratna R, Almeida CF, Tullett KM, Bertolino P, Bowen DG, Cozijnsen A, Mollard V, McFadden GI, Caminschi I, Lahoud MH, Kedzierska K, Turner SJ, Godfrey DI, Hermans IF, Painter GF, Heath WR (2020). Glycolipid-peptide vaccination induces liver-resident memory CD8+ T cells that protect against rodent malaria. Sci Immunol. 5(48):eaaz8035
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Shrestha R, Petley EV, Farrand KJ, Jamieson SA, Jiao W, Teesdale-Spittle PH, Hermans IF, Mace PD, Rendle PM (2020). The Synthesis and Anti-tumour Properties of Poly Ethoxy Ethyl Glycinamide (PEE-G) Scaffolds with Multiple PD-1 Peptides Attached. ChemMedChem.
Bosteels C, Neyt K, Vanheerswynghels M, van Helden MJ, Sichien D, Debeuf N, De Prijck S, Bosteels V, Vandamme N, Martens L, Saeys Y, Louagie E, Lesage M, Williams DL, Tang SC, Mayer JU, Ronchese F, Scott CL, Hammad H, Guilliams M, Lambrecht BN (2020). Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection. Immunity. S1074-7613(20)30163-1.
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George P, Brown A, Weinkove R (2020). B-cell Prolymphocytic Leukaemia With a t(4;14) FGFR3/IGH Translocation: Response to Ibrutinib. Pathology. 52(4):491-492.
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Fabre MS, Stanton NM, Slatter TL, Lee S, Senanayake D, Gordon RMA, Castro ML, Rowe MR, Taha A, Royds JA, Hung N, Melnick AM, McConnell MJ (2020). The oncogene BCL6 is up-regulated in glioblastoma in response to DNA damage, and drives survival after therapy. PLoS One. 15(4):e0231470
Grasso C, Field CS, Tang CW, Ferguson PM, J Compton B, Anderson RJ, Painter GF, Weinkove R, F Hermans I, Berridge MV (2020). Vaccines adjuvanted with an NKT cell agonist induce effective T-cell responses in models of CNS lymphoma. Immunotherapy.
Ferrer-Font L, Mayer JU, Old S, Hermans IF, Irish J, Price KM (2020). High-Dimensional Data Analysis Algorithms Yield Comparable Results for Mass Cytometry and Spectral Flow Cytometry Data. Cytometry A.
Woodhead JST, D'Souza RF, Hedges CP, Wan J, Berridge MV, Cameron-Smith D, Cohen P, Hickey AJR, Mitchell CJ, Merry TL (2020). High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men. J Appl Physiol (1985).
Li Y, Woods K, Parry-Strong A, Anderson RJ, Capistrano C, Gestin A, Painter GF, Hermans IF, Krebs J, Gasser O (2020). Distinct Dysfunctional States of Circulating Innate-Like T Cells in Metabolic Disease. Front Immunol. 11:448
Lasham A, Tsai P, Fitzgerald SJ, Mehta SY, Knowlton NS, Braithwaite AW, Print CG (2020). Accessing a New Dimension in TP53 Biology: Multiplex Long Amplicon Digital PCR to Specifically Detect and Quantitate Individual TP53 Transcripts. Cancers (Basel). 12(3)
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Giladi A, Cohen M, Medaglia C, Baran Y, Li B, Zada M, Bost P, Blecher-Gonen R, Salame TM, Mayer JU, David E, Ronchese F, Tanay A, Amit I (2020). Dissecting cellular crosstalk by sequencing physically interacting cells. Nat Biotechnol. 38(5):629-637
Ferrer-Font L, Pellefigues C, Mayer JU, Small SJ, Jaimes MC, Price KM (2020). Panel Design and Optimization for High-Dimensional Immunophenotyping Assays Using Spectral Flow Cytometry. Curr Protoc Cytom. 92(1):e70
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Robichon K, Patel V, Connor B, La Flamme AC (2020). Clozapine reduces infiltration into the CNS by targeting migration in experimental autoimmune encephalomyelitis. J Neuroinflammation. 17(1):53
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Ferrer-Font L, Mehta P, Harmos P, Schmidt AJ, Chappell S, Price KM, Hermans IF, Ronchese F, le Gros G, Mayer JU (2020). High-dimensional analysis of intestinal immune cells during helminth infection. Elife. 9:e51678
Mehta S, McKinney C, Algie M, Verma CS, Kannan S, Harfoot R, Bartolec TK, Bhatia P, Fisher AJ, Gould ML, Parker K, Cesare AJ, Cunliffe HE, Cohen SB, Kleffmann T, Braithwaite AW, Woolley AG (2020). Dephosphorylation of YB-1 is Required for Nuclear Localisation During G2 Phase of the Cell Cycle. Cancers (Basel). 12(2):315
Stanworth SJ, Killick S, McQuilten ZK, Karakantza M, Weinkove R, Smethurst H, Pankhurst LA, Hodge RL, Hopkins V, Thomas HL, Deary AJ, Callum J, Lin Y, Wood EM, Buckstein R, Bowen D; REDDS Investigators (2020). Red cell transfusion in outpatients with myelodysplastic syndromes: a feasibility and exploratory randomised trial. Br J Haematol. 189(2):279-290
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Lange J, Anderson RJ, Marshall AJ, Chan STS, Bilbrough TS, Gasser O, Gonzalez-Lopez C, Salio M, Cerundolo V, Hermans IF, Painter GF (2020). The Chemical Synthesis, Stability, and Activity of MAIT Cell Prodrug Agonists That Access MR1 in Recycling Endosomes. ACS Chem Biol. 15(2):437-445
2019
Czechowska K, Lannigan J, Aghaeepour N, Back JB, Begum J, Behbehani G, Bispo C, Bitoun D, Fernández AB, Boova ST, Brinkman RR, Ciccolella CO, Cotleur B, Davies D, Dela Cruz GV, Del Rio-Guerra R, Des Lauriers-Cox AM, Douagi I, Dumrese C, Bonilla Escobar DL, Estevam J, Ewald C, Fossum A, Gaudillière B, Green C, Groves C, Hall C, Haque Y, Hedrick MN, Hogg K, Hsieh EWY, Irish J, Lederer J, Leipold M, Lewis-Tuffin LJ, Litwin V, Lopez P, Nasdala I, Nedbal J, Ohlsson-Wilhelm BM, Price KM, Rahman AH, Rayanki R, Rieger AM, Robinson JP, Shapiro H, Sun YS, Tang VA, Tesfa L, Telford WG, Walker R, Welsh JA, Wheeler P, Tárnok A (2019). Cyt-Geist: Current and Future Challenges in Cytometry: Reports of the CYTO 2019 Conference Workshops. Cytometry A. 95(12):1236-1274
Schmidt AJ, Mayer JU, Wallace PK, Ronchese F, Price KM (2019). Simultaneous Polychromatic Immunofluorescent Staining of Tissue Sections and Consecutive Imaging of up to Seven Parameters by Standard Confocal Microscopy. Curr Protoc Cytom. 91(1)
Weng J, Lai P, Qin L, Lai Y, Jiang Z, Luo C, Huang X, Wu S, Shao D, Deng C, Huang L, Lu Z, Zhou M, Zeng L, Chen D, Wang Y, Chen X, Geng S, Weinkove R, Tang Z, He C, Li P, Du X (2019). Correction to: A novel generation 1928zT2 CAR T cells induce remission in extramedullary relapse of acute lymphoblastic leukemia. J Hematol Oncol. 12(1):117
Mayer JU (2020). Commentary: Spatiotemporal Modeling of the Key Migratory Events During the Initiation of Adaptive Immunity. Front Immunol. 10:2311
Clark DW, Eccles D, et al (2019). Associations of autozygosity with a broad range of human phenotypes. Nat Commun. 10(1):4957
La Flamme AC (2019). Immunology & Cell Biology Publication of the Year Awards 2018. Immunol Cell Biol. 97(10):857-858
Dickinson M, Weinkove R (2019). Maintaining a fit T-cell compartment: lymphoma treatment sequencing in the era of chimeric antigen receptor T-cell therapies. Intern Med J. 49(10):1338
Pellefigues C, Mehta P, Prout MS, Naidoo K, Yumnam B, Chandler J, Chappell S, Filbey K, Camberis M, Le Gros G (2019). The Basoph8 Mice Enable an Unbiased Detection and a Conditional Depletion of Basophils. Front Immunol 10:2143
Boykin LM, Sseruwagi P, Alicai T, Ateka E, Mohammed IU, Stanton JL, Kayuki C, Mark D, Fute T, Erasto J, Bachwenkizi H, Muga B, Mumo N, Mwangi J, Abidrabo P, Okao-Okuja G, Omuut G, Akol J, Apio HB, Osingada F, Kehoe MA, Eccles D, Savill A, Lamb S, Kinene T, Rawle CB, Muralidhar A, Mayall K, Tairo F, Ndunguru J (2019). Tree Lab: Portable genomics for Early Detection of Plant Viruses and Pests in Sub-Saharan Africa. Genes (Basel). 21;10(9)
Compton BJ, Farrand KJ, Tang CW, Osmond TL, Speir M, Authier-Hall A, Wang J, Ferguson PM, Chan STS, Anderson RJ, Cooney TR, Hayman CM, Williams GM, Brimble MA, Brooks CR, Yong LK, Metelitsa LS, Zajonc DM, Godfrey DI, Gasser O, Weinkove R, Painter GF, Hermans IF (2019) Enhancing T cell responses and tumour immunity by vaccination with peptides conjugated to a weak NKT cell agonist. Org & Biomol Chem 17(5):1225-1237
Wong J, Wood EM, Crispin P, Weinkove R, McQuilten ZK; Australasian Leukaemia and Lymphoma Group (ALLG) Supportive Care Group (2019) Managing hypogammaglobulinaemia secondary to haematological malignancies in Australia and New Zealand: a clinician survey. Intern Med J49(3):358-363
Neuzil J, Berridge MV (2019) Mitochondria break through cellular boundaries. Aging (Albany NY) 11(13):4308-4309
Neuzil J, Dong L, Berridge M (2019) Cancer’s thieving ways. Australasian Science May/June, 38-39
Xiao AY, Maynard MR, Piett CG, Nagel ZD, Alexander JS, Kevil CG, Berridge MV, Pattillo CB, Rosen LR, Miriyala S, Harrison L (2019) Sodium sulfide selectively induces oxidative stress, DNA damage, and mitochondrial dysfunction and radiosensitizes glioblastoma (GBM) cells. Redox Biol 26:101220
Fischer K, Al-Sawaf O, Bahlo J, Fink AM, Tandon M, Dixon M, Robrecht S, Warburton S, Humphrey K, Samoylova O, Liberati AM, Pinilla-Ibarz J, Opat S, Sivcheva L, Le Dû K, Fogliatto LM, Niemann CU, Weinkove R, Robinson S, Kipps TJ, Boettcher S, Tausch E, Humerickhouse R, Eichhorst B, Wendtner CM, Langerak AW, Kreuzer KA, Ritgen M, Goede V, Stilgenbauer S, Mobasher M, Hallek M (2019) Venetoclax and Obinutuzumab in Patients with CLL and Coexisting Conditions. N Engl J Med 380(23):2225-2236
Hyde EJ, Wakelin KA, Daniels NJ, Ghosh S, Ronchese F (2019) Similar immune mechanisms control experimental airway eosinophilia elicited by different allergens and treatment protocols. BMC Immunol 20(1):18
Weinkove R, George P, Dasyam N, McLellan AD (2019) Selecting costimulatory domains for chimeric antigen receptors: functional and clinical considerations. Clin Transl Immunology 8(5):e1049
Templeton N, Kivell B, McCaughey-Chapman A, Connor B, La Flamme AC (2019) Clozapine administration enhanced functional recovery after cuprizone demyelination. PLoS One 14(5):e0216113
Bouchery T, Le Gros G, Harris N(2019) ILC2s-Trailblazers in the Host Response Against Intestinal Helminths. Front Immunol 10:623
Loope KJ, Baty JW, Lester PJ, Wilson Rankin EE (2019) Pathogen shifts in a honeybee predator following the arrival of the Varroa mite. Proc Biol Sci 286(1894):20182499
Lester PJ, Buick KH, Baty JW, Felden A, Haywood J (2019) Different bacterial and viral pathogens trigger distinct immune responses in a globally invasive ant. Sci Rep 9(1):5780
Van den Elsen LWJ, Tims S, Jones AM, Stewart A, Stahl B, Garssen J, Knol J, Forbes-Blom EE, Van't Land B (2019) Prebiotic oligosaccharides in early life alter gut microbiome development in male mice while supporting influenza vaccination responses. Beneficial Microbes 10(3):279-291
Blecher-Gonen R, Bost P, Hilligan KL, David E, Salame TM, Roussel E, Connor LM, Mayer JU, Bahar Halpern K, Tóth B, Itzkovitz S, Schwikowski B, Ronchese F, Amit I (2019) Single-Cell Analysis of Diverse Pathogen Responses Defines a Molecular Roadmap for Generating Antigen-Specific Immunity. Cell Systems 8(2):109-121.e6
La Flamme AC (2019) Immunology & Cell Biology's top 10 original research articles 2017-2018. Immunol Cell Biol 97(2):119-120
Weinkove R, Bowden E, Wood C, Campion V, Carter J, Hall R, Weatherall M, Beasley R, Young P (2019) A randomized controlled feasibility trial of paracetamol during febrile neutropenia in hemato-oncology patients. Leukemia & Lymphoma 1-8 60(6):1540-1547
Greish K, Nehoff H, Bahman F, Pritchard T, Taurin S (2019) Raloxifene nano-micelles effect on triple-negative breast cancer is mediated through estrogen receptor-β and epidermal growth factor receptor. J Drug Target 27(8):903-916
Bajzikova M, Kovarova J, Coelho AR, Boukalova S, Oh S, Rohlenova K, Svec D, Hubackova S, Endaya B, Judasova K, Bezawork-Geleta A, Kluckova K, Chatre L, Zobalova R, Novakova A, Vanova K, Ezrova Z, Maghzal GJ, Magalhaes Novais S, Olsinova M, Krobova L, An YJ, Davidova E, Nahacka Z, Sobol M, Cunha-Oliveira T, Sandoval-Acuña C, Strnad H, Zhang T, Huynh T, Serafim TL, Hozak P, Sardao VA, Koopman WJH, Ricchetti M, Oliveira PJ, Kolar F, Kubista M, Truksa J, Dvorakova-Hortova K, Pacak K, Gurlich R, Stocker R, Zhou Y, Berridge MV, Park S, Dong L, Rohlena J, Neuzil J (2019) Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells. Cell Metab 29(2):399-416.e10
Filbey K, Camberis M, Chandler J, Turner R, Kettle A, Eichenberger R, Giacomin P, Le Gros G (2019) Intestinal helminth infection promotes IL-5- amd CD4+ T cell-dependent immunity in the lung against migrating parasites. Mucusol Immunolgy 12(2):352-362
2018
Herst PM, Grasso C, Berridge MV (2018) Metabolic reprogramming of mitochondrial respiration in metastatic cancer. Cancer and Metastasis Reviews 37(4):643-653
Berridge MV, Herst PM, Rowe MR, Schneider R, McConnell MJ (2018) Mitochondrial transfer between cells: methodological constraints in cell culture and animal models. Analytical Biochem 552: 75-80
Baey C, Yang J, Ronchese F, Harper JL (2018) HyperuricaemicUrahPlt2/Plt2mice show altered T cell proliferation and defective tumor immunity after local immunotherapy with Poly I:C. PLOS One 13(11):e0206827
Wheeler M, White G, Brockie S, Dickson M, Weinkove R (2018) Flow Cytometric Analysis of Mechanically Disaggregated Bone Marrow Trephine Biopsies. Cytometry B Clin Cytom94(6):935-940
Michelini S, Balakrishnan B, Parolo S, Matone A, Mullaney J, Young W, Gasser O, Priami C, Lombardo R, Kussmann M (2018) A reverse metabolic approach to weaning: In silico identification of immune-beneficial infant gut bacteria, mining their metabolism for prebiotic feeds and sourcing these feeds in the natural product space. Microbiome 6(1):171
Herst PM, Dawson, RH, Berridge MV (2018) Intercellular communication in Tumour Biology: A Role for Mitochondrial Transfer. Frontiers in Oncol 8:344
Poyntz, HC, Jones A, Jauregui R, Young W, Gestin A, Mooney A, Lamiable O, Altermann E, Schmidt A, Gasser O, Weyrich L, Jolly CJ, Linterman MA, Le Gros G, Hawkins ED, Forbes-Blom E (2018) Genetic regulation of antibody responsiveness to immunization in substrains or BALB/c mice. Immunol & Cell Biol 97(1):39-53
Schalamun M, Nagar R, Kainer D, Beavan E, Rathjen J, Eccles D, Lanfear R, Schwessinger B (2018) Harnessing the MinION: An example of how to establish long-read sequencing in a laboratory using challenging plant tissue from Eucalyptus pauciflora. Mol Ecol Resources 19(1):77-89
Naidoo K, Jagot F, van den Elsen L, Pellefigues C, Jones A, Lu H, Johnston K, Painter G, Roediger B, Lee J, Weninger W, Le Gros G, Forbes-Blom E (2018) Eosinophils determine dermal thickening and water loss in a MC903 model of atopic dermatitis. J Invest Dermatol.
Prout MS, Kyle RL, Ronchese F, Le Gros G (2018) IL-4 is a key requirement for IL-4 and IL-4/IL-13 expressing CD4 Th2 subsets in lung and skin. Front Immunol 9:1211
Bezawork-Geleta A, Wen H, Dong L, Yan B, Vider J, Boukalova S, Krobova L, Vanova K, Zobalova R, Sobol M, Hozak P, Novais SM, Caisova V, Abaffy P, Naraine R, Pang Y, Zaw T, Zhang P, Sindelka R, Kubista M, Zuryn S, Molloy MP, Berridge MV, Pacak K, Rohlena J, Park S, Neuzil J (2018) Alternate assembly of SDHA connects energy stress to metabolic checkpoint and DNA synthesis. Nat Commun 9(1):2221
Prendergast KA, Daniels NJ, Petersen TR, Hermans IF, Kirman JR (2018) Langerin + CD8α+ Dendritic Cells Drive Early CD8+ T Cell Activation and IL-12 Production During Systemic Bacterial Infection. Front Immunol 9:953
Werder RB, Lynch JP, Simpson JC, Zhang V, Hodge NH, Poh M, Forbes-Blom E, Kulis C, Smythe ML, Upham JW, Spann K, Everard ML, Phipps S (2018) PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN-λ production. Sci Transl Med. 9;10(440)
Shortt, N, Poyntz H, Young W, Jones A, Gestin A, Mooney A, Thayabaran D, Sparks J, Ostapowicz T, Tay A, Poppitt S, Elliott S, Wakefield G, Parry-Strong A, Ralston J, Gasser O, Beasley R, Weatherall M, Braithwaite I, Forbes-Blom E (2018) A feasibility study: association between gut microbiota enterotype and antibody response to seasonal trivalent influenza vaccine in adults. Clin Transl Immunol 7(3):1013
Hall CJ, Sanderson LE, Lawrence LM, Pool B, van der Kroef M, Ashimbayeva E, Britto D, Harper JL, Lieschke GJ, Astin JW, Crosier KE, Dalbeth N, Crosier PS (2018)Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation. J Clin Invest. 1;128(5):1752-1771.
Bouchery T, Filbey K, Shepherd A, Chandler J, Patel D, Schmidt AJ, Camberis M, Peignier A, Smith AAT, Johnston K, Painter G, Pearson M, Giacomin P, Le Gros G (2018) A novel blood feeding detoxification pathway in Nippostrongylus brasiliensis L3 reveals a potential checkpoint for arresting Hookworm development. PLoS Pathog 14(3)
Weng J, Peilong L, Le Q, Yunxin L, Zhiwu J, Chenwei L, Xin H, Suijin W, Shao D, Chengxin D, Lisi H, Zesheng L, Maohua Z, Lingji Z, Dongmei C, Yulian W, Xiaomei C, Suxia G, Weinkove R, Zhaoyang T, Chang H, Peng L, Xin D (2018) A novel generation 1928zT2 CAR T cells induce remission in extramedullary relapse of acute lymphoblastic leukemia. J Hemat Oncol 11(1):25
Gilfillan CB, Kuhn S, Baey C, Hyde EJ, Yang J, Ruedl C, Ronchese F (2018) Clec9A + dendritic cells are not essential for anti-tumor CD8 + T Cell responses induced by poly I:C immunotherapy. J Immunol 200(8):2978-2986
Wickens K, Barthow C, Mitchell EA, Stanley TV, Purdie G, Rowden J, Kang J, Hood F, van den Elsen L, Forbes-Blom E, Franklin I, Barnes P, Fitzharris P, Maude RM, Stone P, Abels P, Murphy R, Crane J (2018) Maternal supplementation alone with Lactobacillus rhamnosus HN001 during pregnancy and breastfeeding does not reduce infant eczema. Pediatr Allergy Immunol 29(3):296-302
Ochiai S, Jagot F, Kyle RL, Hyde E, White RF, Prout M, Schmidt AJ, Yamane H, Lamiable O, Le Gros G, Ronchese F (2018) Thymic stromal lymphopoietin drives the development of IL-13 + Th2 cells. PNAS USA 115(5)1033-1038
Eccles DA, Chandler J, Camberis M, Henrissat B, Koren S, Le Gros G, Ewbank JJ (2018) De novo assembly of the complex genome of Nippostrongylus brasiliensis using MinION long reads. BMC Biol 16(1):6
Pellefigues C, Dema B, Lamri Y, Saidoune F, Chavarot N, Loheac C, Pacreau E, Dussiot M, Bidault C, Marquet F, Jablonski M, Chemouny J, Jouan F, Dossier A, Chauveheid M, Gobert D, Papo T, Karasuyama H, Sacre K, Daugas E, Charles N (2018) Prostaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs. Nat Commun 9(1):725
Gasser O, Sharples KJ, barrow C, Williams GM, Bauer E, Wood CE, Mester B, Dzhelali M, Caygill G, Jones J, Haman CM, Hinder VA, Macapagal J, McCuster M, Weinkove R, Painter GF, Brimble MA, Findlay MP, Dunbar PR, Hermans IF (2018) A phase I vaccination study with dendritic cells loaded with NY-ESO-1 & a-galactosylceramide: induction of polyfunctional T cells in high risk melanoma patients.Cancer Immunol Immunother 67(2):285-298
White MPJ, Webster G, Leonard F, La Flamme AC (2018) Innate IFN-γ ameliorates experimental autoimmune encephalomyelitis and promotes myeloid expansion and PDL-1 expression. Sci Rep. 8(1):259.
Salio M, Gasser O, Gonzalez-Lopez C, Martens A, Veerapen N, Gileadi U, Verter JG, Napolitani G, Anderson R, Painter G, Besra GS, Hermans IF, Cerundolo V (2018) Activation of Human Mucosal-Associated Invariant T Cells Induces CD40L-Dependent Maturation of Monocyte-Derived and Primary Dendritic Cells.J Immunol 199(8)2631:2638
2017
Bradshaw G, Lualhati R, Albury C, Maksemous N, Roos-Araujo D, Smith RA, Benton MC, Eccles DA, Lea RA, Sutherland HG, Haupt LM, Griffiths LR (2018) Exome Sequencing Diagnoses X-Linked Moesin-Associated Immunodeficiency in a Primary Immunodeficiency Case. Front Immunol 9:420
Brooks CR, Van Dalen CJ, Harding E, Hermans IF, Douwes J (2017) Effects of treatment changes on asthma phenotype prevalence and airway neutrophil function.BMC Pulm Med. 17(1):169
Field CS, Hunn MK, Ferguson PM, Ruedl C, Ancelet LR, Hermans IF (2017) Blocking CTLA-4 while priming with a whole cell vaccine reshapes the oligoclonal T cell infiltrate and eradicates tumors in an orthotopic glioma model. Oncoimmunology 7(1)
Bouchery T, Volpe B, Shah K, Lebon L, Filbey K, LeGros G, Harris N (2017) The study of host immune responses elicited by the model murine hookworms Nippostrongylus brasiliensis and Heligmosomoides polygyrus. Curr Prot Mouse Biol 7(4):236-286
Pellefigues C, Tang SC, Schmidt A, White RF, Lamiable O, Connor LM, Ruedl C, Dobrucki J, Le Gros G, Ronchese F (2017) Toll-Like Receptor 4, but Not Neutrophil Extraceullular Traps, Promote IFN Type I Expression to Enhance Th2 Responses to Nippostrongylus brasiliensis. Front Immunol 8:1575
Herst PM, Rowe MR, Carson GM, Berridge MV (2017) Functional Mitochondria in Health and Disease. Front Endocrinol 8:296
Berridge MV, Herst PH, Rowe MR, Schneider R, McConnell MJ (2017) Mitochondrial transfer between cells: methodological constraints in cell culture and animal models. Analytical Biochem 552:75-80
Speir M, Authier-Hall A, Brooks CR, Farrand KJ, Compton BJ, Anderson RJ, Heiser A, Osmond TL, Tang CW, Berzofsky JA, Terabe M, Painter GF, Hermans IF, Weinkove R (2017) Glycolipid-peptide conjugate vaccines enhance CD8+ T cell responses against human viral proteins. Scientific Reports7:14273
Anderson RJ, Li J, Kedzierski L, Comton BJ , Hayman CM, Osmond TL, Tang C, Farrand KJ, Koay H, Dos Santos Sa E CF, Almeida, Holz LR, Williams GM, Trimble MA, Wang Z, Koutsakos M, Kedzierska K, Godfrey DI, Hermans IF, Turner SJ, Painter GF (2017) Augmenting Influenza-Specific T Cell Memory Generation with a Natural Killer T Cell-Dependent Glycolipid-Peptide Vaccine. ACS Chemical Biology 12(11)2898-2905
Feldman LA, Fabre MS, Grasso C, Reid D, Broaddus WC, Lanza GM, Spiess BD, Garbow JR, McConnell MJ, Herst PM (2017) Perfluorocarbon emulsions radiosensitise brain tumors in carbogen breathing mice with orthotopic GL261 gliomas. PLoS One. 12(9).
McGrath AJ, Dolan C, Cheong S, Herman DAJ, Naysmith B, Zong F, Galvosas P, Farrand KJ, Hermans IF, Brimble M, Williams DE, Jin J, Tiley RD (2017) Stability of polyelectrolyte-coated iron nanoparticles for T2-weighted magnetic resonance imaging. J Magnetism & Magnetic Materials 439:251-258
Lucas N, Humble M, Sim D, Balm M, Carter JM and Weinkove R (2017) Temporal changes in neutropenic blood culture isolates: and disease associations: a single centre series of 1139 episodes. Int Med J 47(8):962-965
Robinson MJ, Prout M, Mearns H, Kyle R, Camberis M, Forbes-Blom EE, Paul WE, Allen CDC, Le Gros G (2017) IL-4 Haploinsufficiency Specifically Impairs IgE Responses against Allergens in Mice. J Immunol.
Dong L-F, Kovarova J, Bajzikova M, Bezawork-Geleta A, Svec D, Endaya B, Sachaphibulkij K, Coelho AR, Sebkova N, Ruzickova A, Tan AS, Kluckova K, Judasova K, Zamecnikova K, Rychtarcikova Z, Gopalan V, Andera L, Sobol M, Yan B, Pattnaik B, Bhatraju N, Truksa J, Stopka P, Hozak P, Lam A, Sedlacek, R, Oliveira P, Kubista M, Agrawal A, Dvorakova-Hortova K, Rohlena J, Berridge MV, Neuzil J (2017) Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells. eLife
Berridge MV, Neuzil J (2017) The mobility of mitochondria: intercellular trafficking in health and disease.Clinical and Experimental Pharmacology and Physiology.
Chandler J, Camberis M, Bouchery T, Blaxter M, Le Gros G, Eccles DA. (2017) Annotated mitochondrial genome with Nanopore R9 signal for Nippostrongylus brasiliensis. F1000Res.
Stuart S, Benton MC, Eccles DA, Sutherland HG, Haupt LM, Lea RA, Griffiths LR. (2017) Gene-centric analysis implicates nuclear encoded mitochondrial protein gene variants in migraine susceptibility. Mol Genet Genomic Med.
Connor LM, Tang SC, Cognard E, Ochiai S, Hilligan KL, Old SI, Pellefigues C, White RF, Patel D, Smith AA, Eccles DA, Lamiable O, McConnell MJ, Ronchese F. (2017) Th2 responses are primed by skin dendritic cells with distinct transcriptional profiles. J Exp Med.
McGrath, A.J, Dolan, C., Cheong-Tilley, S., Herman, D.A.J, Naysmith, B., Zong, F., Galvonas, P, Farrand, K.J., Hermans, I.F., Brimble., M.A., Williams, D., Jin, J. and Tilley, R.D. (2017) Stability of polyelectrolyte-coated iron nanoparticles for T2-weighted magnetic resonance imaging. Journal of Magnetism and Magnetic Materials In press
Brooks, C.R., van Dalen, C.J., Hermans, I.F., Gibson, P.G., Simpson, J.L., and Douwes, J. (2017) Sputum basophils are increased in eosinophilic asthma compared with non-eosinophilic asthma phenotypes. Allergy.
Speir, M., Hermans, I.F. and Weinkove, R. (2017) Engaging natural killer T cells as 'universal helpers' for vaccination. Drugs
2016
Berridge MV, McConnell MJ, Grasso C, Bajzikova M, Kovarova J, Neuzil J (2016) Horizontal transfer of mitochondria between mammalian cells: beyond co-culture approaches. Curr Opin Genetics Dev
Berridge MV, Schneider R, McConnell MJ (2016) Mitochondrial transfer from astrocytes to neurons following ischemic insult: guilt by association? Cell Metab
Bouchery T, Camberis M, Le Gros G (2016) Dye Labeling of Live Nippostrongylus brasiliensis Larvae for Visualization in Host Tissue. Bio-protocol
Camberis M, Bouchery T, Le Gros G (2016) Isolation of Nippostrongylus brasiliensis Larvae from Mouse Lungs. Bio-protocol
Collings S, Thompson O, Hirst E, Goossens L, George A, Weinkove R (2016) Non-Invasive Detection of Anaemia Using Digital Photographs of the Conjunctiva. PLoS One
Eccles DA, Chambers GK, Lea RA (2016) Estimation of Genomic Ancestry in Admixed Populations via Population Sub-sampling. F1000Res
Grasso C, Anaka M, Hofmann O, Sompallae R, Broadley K, Hide W, Berridge MV, Cebon J, Behren A, McConnell MJ (2016) Iterative sorting of CD133+ and CD133- melanoma cells indicates two phenotypically distinct populations. BMC Cancer
Hilligan KL, Connor LM, Schmidt AJ, Ronchese F (2016) Activation-Induced TIM-4 Expression Identifies Differential Responsiveness of Intestinal CD103+ CD11b+ Dendritic Cells to a Mucosal Adjuvant. PLoS One
Le Gros G, Kyle R (2016) The Differentiation and Function of Th2 and Th9 Cells. Encyclopedia of Immunobiology
Price KM, Muirhead KA, Wallace PK (2016) Proliferation by many other names: Monitoring cell cycle progression and cell division by flow cytometry. Cytometry A
Roth I, Campbell H, Rubio C, Vennin C, Wilson M, Wiles A, Williams G, Woolley A, Timpson P, Berridge MV, Fleming N, Baird M, Braithwaite A (2016) The Δ133p53 isoform and its mouse analogue Δ122p53 promote invasion and metastasis involving pro-inflammatory molecules interleukin-6 and CCL2. Oncogene
Schmidt A, Bouchery T, Le Gros G, Price KM (2016) Large Particle Sorting to Isolate Live Parasitic Nematode Eggs. Curr Protoc Cytom
Waghorne CL, Corkran HM, Hunt-Painter AA, Niktab E, Baty JW, Berridge MV, Munkacsi AB, McConnell MJ, Timmer MS, Stocker BL (2016) N,N-Bis(glycityl)amines as anti-cancer drugs. Bioorg Med Chem
Speir M, Kate E, Lawlor KE, Glaser SP, Abraham G, Chow S, Vogrin A, Schulze KE, Schuelein R, O’Reilly LA, Mason K, Hartland EL, Lithgow T, Strasser A, Lessene G, Huang DCS, Vince JE, Naderer T (2016) Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis. Nat Microbiol
2015
Anderson RJ, Compton BJ, Tang C, Authier-Hall A, Hayman CM, Swinerd GW, Kowalczyk R, Harris P, Brimble MA, Larsen DS, Gasser O, Weinkove R, Hermans IF, Painter GF. (2015). NKT Cell-Dependent Glycolipid-Peptide Vaccines with Potent Anti-tumour Activity. Chem. Sci.
Daniels NJ, Hyde E, Ghosh S, Seo K, Price KM, Hoshino K, Kaisho T, Okada T, Ronchese F. (2015) Antigen-specific cytotoxic T lymphocytes target airway CD103+ and CD11b+ dendritic cells to suppress allergic inflammation. Mucosal Immunol.
Hewitson JP, Filbey KJ, Esser-von Bieren J, Camberis M, Schwartz C, Murray J, Reynolds LA, Blair N, Robertson E, Harcus Y, Boon L, Ching-Cheng Huang S, Yang L, Tu L, Miller MJ, Voehringer D, Le Gros G, Harris N, Maizels RM. (2015). Concerted Activity of IgG1 Antibodies and IL-4/IL-25-Dependent Effector Cells Trap Helminth Larvae in the Tissues following Vaccination with Defined Secreted Antigens, Providing Sterile Immunity to Challenge Infection. PLOS Pathogens
Tan AS, Baty JW, Dong LF, Bezawork-Gelata A, Endaya B, Goodwin J, Bajzikova M, Kovarova J, Peterka M; Yan B, Pesdar EA, Sobol M, Filimonenko A, Stuart S, Vondrusova M, Kluckova K; Sachaphibulkij K, Rohlena J, Hozak P, Truska J, Eccles D, Haupt L, Griffiths L, Neuzil J, Berridge MV (2015) Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA. Cell Metabolism.
Benton MC, Lea RA, Macartney-Coxson D, Bellis C, Carless MA, Curran JE, Hanna M, Eccles DA, Chambers GK, Blangero J, Griffiths JR (2015) Serum bilirubin concentration is modified by UGT1A1 Haplotypes and influences risk of Type-2 diabetes in the Norfolk Island genetic isolate. BMC Genet
Benton MC, Lea RA, Macartney-Coxson D, Hanna M, Eccles DA, Carless MA, Chambers GK, Bellis C, Goring HH, Curran JE, Harper JL, Gibson G, Blangero J, Griffiths LR (2015) A phenomic scan of the Norfolk Island genetic isolate identifies a major pleiotropic effect locus associated with metabolic and renal disorder markers. PLoS Genet
Berridge MV, Dong L, Neuzil J (2015) Mitochondrial DNA in tumor initiation, progression and metastasis: role of horizontal mtDNA transfer. Cancer Res
Berridge MV, Grasso C, Neuzil J (2015) Mitochondrial genome transfer to tumour cells breaks the rules and establishes a new precedent in cancer biology. Mol Cell Oncol
Bouchery T, Kyle R, Camberis M, Shepherd A, Filbey K, Smith A, Harvie M, Painter G, Johnston K, Ferguson P, Jain R, Roediger B, Delahunt B, Weninger W, Forbes-Blom E, Le Gros G (2015) ILC2s and T cells cooperate to ensure maintenance of M2 macrophages for lung immunity against hookworms. Nat Commun
Compton BJ, Tang C, Johnston KA, Osmond TL, Hayman CM, Larsen DS, Hermans IF, Painter GF (2015) Synthesis and Activity of 6″-Deoxy-6″-thio-α-GalCer and Peptide Conjugates. Org Lett
Dalbeth N, Pool B, Shaw OM, Harper JL, Tan P, Franklin C, House ME, Cornish J, Naot D (2015) Role of miR-146a in regulation of the acute inflammatory response to monosodium urate crystals. Ann Rheum Dis
Daniels NJ, Hyde E, Ghosh S, Seo K, Price KM, Hoshino K, Kaisho T, Okada T, Ronchese F (2015) Antigen-specific cytotoxic T lymphocytes target airway CD103+ and CD11b+ dendritic cells to suppress allergic inflammation. Mucosal Immunol
Gibbins JD, Ancelet LR, Osmond TL, Petersen TR, Hermans IF (2015) Splenic dendritic cells involved in cross-tolerance of tumor antigens can play a stimulatory role in adoptive T cell therapy. J Immunother
Hewitson JP, Filbey KJ, Bieren JE, Camberis M, Schwartz C, Murray J, Reynolds LA, Blair N, Robertson E, Harcus Y, Boon L, Huang SC-C, Yang L, Tu Y, Miller MJ, Voehringer D, Le Gros G, Harris N, Maizels RM (2015) Concerted Activity of IgG1 Antibodies and IL-4/IL-25-Dependent Effector Cells Trap Helminth Larvae in the Tissues following Vaccination with Defined Secreted Antigens, Providing Sterile Immunity to Challenge Infection. PLoS Pathog
Ip CL, Loose M, Tyson JR, de Cesare M, Brown BL, Jain M, Leggett RM, Eccles DA, Zalunin V, Urban JM, Piazza P, Bowden RJ, Paten B, Mwaigwisya S, Batty EM, Simpson JT, Snutch TP, Birney E, Buck D, Goodwin S, Jansen HJ, O'Grady J, Olsen HE (2015) MinION Analysis and Reference Consortium, Research Article: MinION Analysis and Reference Consortium: Phase 1 data release and analysis F1000Res
Jang JC, Chen G, Wang SH, Barnes MA, Chung JI, Camberis M, Le Gros G, Cooper PJ, Steel C, Nutman TB, Lazar MA, Nair MG (2015) Macrophage-derived human resistin is induced in multiple helminth infections and promotes inflammatory monocytes and increased parasite burden. PLoS Pathog
Kodar K, Eising S, Khan AA, Steiger S, Harper JL, Timmer MS, Stocker BL (2015) The uptake of trehalose glycolipids by macrophages is independent of Mincle. Chembiochem
Kuhn S, Yang J, Hyde E, Harper J, Kirman J, Ronchese F (2015) L-1beta receptor-dependent priming of anti-tumor CD4 T cells and sustained anti-tumor immunity after peri-tumoral treatment with MSU and mycobacteria. OncoImmunology
Kuhn S, Yang J, Ronchese F (2015) Monocyte-derived dendritic cells are essential for CD8+ T cell activation and anti-tumor responses after local immunotherapy. Front Immunol
Mester B, Bauer B, Wood CE, Hermans IF, Gasser O (2015) Expression of CD1a and Type-1 polarization are dissociated in human monocyte-derived dendritic cells. PLoS One
Osmond TL, Farrand KJ, Painter GF, Ruedl C, Petersen TR, Hermans IF (2015) Activated NKT cells can condition different splenic dendritic cell subsets to respond more effectively to toll-like receptor engagement and enhance cross-priming. J Immunol
Reuter H, Maerz M, Vogg MC, Eccles D, Grifol-Boldu L, Wehner D, Owlarn S, Adell T, Weidinger G, Bartscherer K (2015) β-Catenin-Dependent Control of Positional Information along the AP Body Axis in Planarians Involves a Teashirt Family Member. Cell Rep
Steiger S, Kuhn S, Ronchese F, Harper J (2015) MSU crystals induce upregulation of NK1.1-dependent killing by macrophages and support tumor-resident NK1.1+ monocyte/macrophage populations in anti-tumor therapy. J Immunol
Tan AS, Baty JW, Dong LF, Bezawork-Geleta A, Endaya B, Goodwin J, Bajzikova M, Kovarova J, Peterka M, Yan B, Pesdar EA, Sobo M, Filimonenko A, Stuart S, Vondrusova M, Kluckova K, Sachaphibulkij K, Rohlena J, Hozak P, Truksa J, Eccles D, Haupt LM, Griffiths LR, Neuzil J, Berridge MV (2015) Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA. Cell Metab
Vieira AT, Macia L, Galvao I, Martins FS, Canesso M CC, Amaral FA, Garcia CC, Maslowski KM, De Leon E, Shim D, Nicoli JR, Harper JL, Teixeira MM, Mackay CR (2015) A Role for Gut Microbiota and the Metabolite-Sensing Receptor GPR43 in a Murine Model of Gout. Arthritis Rheum
Walsh M, White G, Romeril K, Buyck H, Stephens M, Brooks C, Weinkove R (2015) Innate-like T cell profile in myeloma: severe deficiency of Vγ9Vδ2 T cells in aminobisphosphonate-treated patients. Leuk Lymphoma
Weinkove R, Ancelet LR, Gibbins JD, Hermans IF (2015) An adjuvanted whole cell vaccine as postremission immunotherapy for acute leukemia. Oncoimmunology
2014
Castro LM, McConnell MJ, Herst PM (2014) Radiosensitisation by pharmacological ascorbate in glioblastoma multiforme cells, human glial cells, and HUVECs depends on their antioxidant and DNA repair capabilities and is not cancer specific. Free Radic Biol Med & Frontiers in Oncology
Chuluundorj D, Harding SA, Abernethy D, La Flamme AC (2014) Expansion and preferential activation of the CD14+CD16+ monocyte subset during multiple sclerosis. Immunol Cell Biol
Connor LM, Tang SC, Camberis M, Le Gros G, Ronchese F (2014) Helminth–conditioned dendritic cells prime CD4+ T cells to IL-4 production in vivo. J. Immunol
Mearns H, Forbes-Blom EE, Camberis M, Tang SC, Kyle R, Harvie M, Kleinschek MA, Le Gros G IL-25 exhibits disparate roles during Th2-cell differentiation versus effector function. Eur J Immunol
McConnell MJ, Herst PM (2014) Ascorbate combination therapy: new tool in the anticancer toolbox? Sci Transl Med
Ochiai S, Roediger B, Abtin A, Shklovskaya E, Fazekas de St Groth B, Yamane H, Weninger W‡, Le Gros G, Ronchese F (2014) CD326loCD103loCD11blo dermal dendritic cells are activated by Thymic Stromal Lymphopoietin during contact sensitization in mice. J Immunol.
Shaw OM, Pool B, Dalbeth N, Harper JL The effect of diet-induced obesity on the inflammatory phenotype of non-adipose-resident macrophages in an in vivo model of gout. Rheumatology (Oxford)
Shaw OM, Steiger S, Liu X, Hamilton JA, Harper JL GM-CSF drives MSU crystal-induced inflammatory macrophage differentiation and NLRP3 inflammasome upregulation in vivo. Arthritis Rheumatol
Steiger S, Harper JL (2014) Mechanisms of spontaneous resolution of acute gouty inflammation. Curr Rheumatol Rep
Tan AS, Baty JW, Berridge MV (2014) The role of mitochondrial electron transport in tumorigenesis and metastasis. Biochim Biophys Acta
White M, Webster G, O’Sullivan D, Stone S, La Flamme AC (2014) Targeting innate receptors with MIS416 reshapes Th responses and suppresses CNS disease in a mouse model of multiple sclerosis. PLoS One
Anderson RJ, Tang C, Daniels NJ, Compton BJ, Hayman CM, Johnston KA, Knight DA, Gasser O, Poyntz HC, Ferguson PM, Larsen DS, Ronchese F, Painter GF, Hermans, IF. ‘A novel synthetic self-adjuvanting lipopeptide vaccine to induce cytotoxic T lymphocytes that suppress allergic disease’. Nature Chemical Biology.
Authier A, Farrand KJ, Broadley KWR, Stone S, Hunn MK, Ancelet LR, McConnell MJ, Hermans IF. (2014) Enhanced immunosuppression by therapy-exposed glioblastoma multiforme tumor cells. Int J Cancer.
Bouchery T, Kyle R, Ronchese F, Le Gos G. (2014) The differentiation of CD4+ T-helper cell subsets in the context of helminth parasite infection. Review article. Frontiers Immunol.
Castro LM, McConnell MJ, Herst PM. (2014) Radiosensitisation by pharmacological ascorbate in glioblastoma multiforme cells, human glial cells, and HUVECs depends on their antioxidant and DNA repair capabilities and is not cancer specific. Free.Radic.Biol.Med.
Connor LM, Tang SC, Camberis M, Le Gros G, Ronchese F (2014) Helminth–conditioned dendritic cells prime CD4+ T cells to IL-4 production in vivo. J. Immunol.
Fleming S, Yannakou C K, Haeusler GM, Clark J, Grigg A, Heath CH, Bajel A, van Hal SJ, Chen S, Milliken ST, Morrissey CO, Tam. J. Szer CS, Weinkove R, Slavin M. (2014) Consensus guidelines for antifungal prophylaxis in haematological malignancy and haemopoietic stem cell transplantation. Intern Med J.
Grasso C, Fabre MS, Collis SV, Castro ML, Field CS, Schleich N, McConnell MJ, Herst PM. (2014). Pharmacological doses of daily ascorbate protect tumors from radiation damage after a single dose of radiation in an intracranial mouse glioma model. Front Oncol.
Gibbins JD, Ancelet LR, Weinkove R, Compton BJ, Painter GF,, Petersen TR, Hermans IF. (2014). An autologous leukemia cell vaccine prevents murine acute leukemia relapse after cytarabine treatment. Blood.
Hunn MK, Bauer E, Wood CE, Gasser O, Dzhelali M, Ancelet LR, Mester B, Sharples KJ, Findlay MP, Hamilton DA, and Hermans IF. (2014). Dendritic cell vaccination combined with temozolomide retreatment: Results of a phase I trial in patients with recurrent glioblastoma multiforme . Journal of Neuro-Oncology.
Ochiai S, Roediger B, Abtin A, Shklovskaya E,Fazekas de St Groth B, Yamane H, Weninger‡ W, Le Gros G, Ronchese.F. (2014). CD326loCD103loCD11blo dermal dendritic cells are activated by Thymic Stromal Lymphopoietin during contact sensitization in mice. J Immunol.
Prendergast KA, Osmond TL, Ochiai S, Hermans IF and Kirman JR. (2014). Sustained in vivo depletion of splenic langerin+ CD8<alpha>+ dendritic cells is well-tolerated by lang-DTREGFP mice. J Immunol. Methods
Mecozzi VJ, Berman DE, Simoes S, Vetanovetz C, Awal MR, Patel VM, Schneider RT, Petsko GA, Ringe D, Small SA. (2014). Pharmacological chaperones stabilize retromer to limit APP processing. N. Chem. Bio.
Nyanhanda T, Gould EM, McGhie T, Shaw OM, Harper JL, Hurst RD. (2014) Blackcurrant polyphenolic cultivar extracts suppress CCL26 secretion from alveolar epithelial cells. Food and Function.
Petersen TR, Knight DA, Ching-Wen T, Osmond TL, Hermans IF. (2014) "Batf3-independent langerin- CX3CR1- CD8α+ splenic DCs represent a precursor for classical cross-presenting CD8α+ DC. Journal of Leukocyte Biology
Roediger B, Kyle R, Le Gros G, Weninger W. (2014) Dermal group 2 innate lymphoid cells in atopic dermatitis and allergy. Curr. Op. Immunol.
Shaw OM, Pool B, Dalbeth N, Harper JL (2014) The effect of diet-induced obesity on the inflammatory phenotype of non-adipose-resident macrophages in an in vivo model of gout. Rheumatol.
Shaw OM, Steiger S, Liu X, Hamilton JA, Harper JL (2014) Granulocyte-Macrophage Colony-Stimulating factor drives monosodium urate monohydrate crystal-induced inflammatory macrophage differentiation and NLRP3 inflammasome up-regulation in an in vivo mouse model. Arthritis & Rheumatol.
Sotillo J, Sanchez-Flores A, Cantacessi C, Harcus Y, Pickering D, Bouchery T, Camberis M, Tang SC, Giacomin P, Mulvenna J, Mitreva M, Berriman M, Le Gros G, Maizels RM, Loukas A. (2014) Secreted Proteomes of Different Developmental Stages of the Gastrointestinal Nematode Nippostrongylus brasiliensis. Molecular & Cellular Proteomics.
Timmer MSM, Sauvageau J, Foster AJ, Ryan J, Lagutin K, Shaw O, Harper JL, Sims IM, Stocker BL. (2014) Discovery of Lipids from B. longum subsp. infantis using Whole Cell MALDI Analysis. J. Org. Chem.
Berridge MV, Dong L, Neuzil J. (2015) Mitochondrial DNA in tumour initiation, progression and metastasis: role of horizontal mtDNA transfer. Cancer Research
Weinkove R, Bailey M, Bellomo R, Saxena MK, Tam CS, Pilcher DV, Beasley D and Young PJ. (2014) Association between early peak temperature and mortality in neutropenic sepsis. Ann Hematol.
2013
Ataera H, Simkins HM, Hyde E, Yang J, Hermans IF, Petersen TR, Ronchese F The control of CD8+ T cell responses is preserved in perforin-deficient mice and released by depletion of CD4+ CD25+ regulatory T cells. J Leukoc Biol
Brooks CR, van Dalen CJ, Hermans IF, Douwes J (2013) Identifying leukocyte populations in fresh and cryopreserved sputum using flow cytometry. Cytometry B Clin Cytom
Camberis M, Prout M, Tang SC, Forbes-Blom E, Robinson M, Kyle R, Belkaid Y, Paul W, Le Gros G (2013) Evaluating the in vivo Th2 priming potential among common allergens. J Immunol Methods
Corkran HM,Munneke S, Dangerfield EM, Stocker BL,Timmer MSM Applications and limitations of the I2-mediated carbamate annulation for the synthesis of piperidines: 5- versus 6-membered cyclisation. J Org Chem
Ferguson PM, Feindel KW, Slocombe A, MacKay M, Wignall T, Delahunt B, Tilley RD, Hermans IF (2013) Strongly magnetic iron nanoparticles improve the diagnosis of small tumours in the reticuloendothelial system by magnetic resonance imaging. PLoS One
Ferguson PM, Slocombe A, Tilley RD, Hermans IF (2013) Using magnetic resonance imaging to evaluate dendritic cell-based vaccination. PLoS One
Grainger R, McLaughlin RJ, Harrison AA, Harper JL (2013) Hyperuricaemia elevates circulating CCL2 levels and primes monocyte trafficking in subjects with inter-critical gout. Rheumatology (Oxford)
Grasso C, Larsen L, McConnell M, Smith RA, Berridge MV (2013) Anti-leukemic activity of ubiquinone-based compounds targeting trans-plasma membrane electron transport. J Med Chem
Harvie M, Camberis M, Le Gros G (2013) Development of CD4 T cell dependent immunity against N. brasiliensis infection. Front Immunol
Herst PM, Berridge MV (2013) Cell hierarchy, metabolic flexibility and systems approaches to cancer treatment. Curr Pharm Biotechnol
Hunn MK, Hermans IF (2013) Exploiting invariant NKT cells to promote T cell responses to cancer vaccines. Oncoimmunology
Johnston LR, Larsen PD, La Flamme AC, Harding SA (2013) Methodological considerations for the assessment of ADP induced platelet aggregation using the Multiplate® analyser. Platelets
Johnston LR, Larsen PD, La Flamme AC, Michel JM, Harding SA (2013) Suboptimal response to clopidogrel and the effect of prasugrel in acute coronary syndromes. Int J Cardiol
Khan AA, Kamena F, Timmer MSM, Stocker BL (2013) Development of a benzophenone and alkyne functionalised trehalose probe to study trehalose dimycolate binding proteins. Org Biomol Chem
Kuhn S, Hyde EJ, Yang J, Rich FJ, Harper JL, Kirman JR, Ronchese F Increased numbers of monocyte-derived dendritic cells during successful tumor immunotherapy with immune-activating agents. J Immunol
Prendergast KA, Kirman JR (2013) Dendritic cell subsets in mycobacterial infection: control of bacterial growth and T cell responses. Tuberculosis (Edinb)
Roediger B, Kyle R, Ho Yip K, Sumaria N, Guy TV, Kim BS, Mitchell AJ, Tay SS, Jain R, Forbes-Blom E, Chen X, Tong PL, Bolton HA, Artis D, Paul WE, Fazekas de St Groth B, Grimbaldeston MA, Le Gros G, Weninger W (2013) Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells. Nat Immunol
Roohullah A, Moniwa A, Wood C, Humble M, Balm M, Carter J, Weinkove R Imipenem versus piperacillin/tazobactam for empiric treatment of febrile neutropenia in adults. Intern Med J, (in press)
Shaw OM, Harper JL An efficient single prime protocol for the induction of antigen-induced airways inflammation. J Immunol Methods, (in press)
Slaney CY, Toker A, Fraser JD, Harper JL, Bäckström BT (2013) A modified superantigen rescues Ly6G-CD11b+ blood monocyte suppressor function and suppresses antigen-specific inflammation in EAE. Autoimmunity
Steiger S, Harper JL (2013) Neutrophil cannibalism triggers transforming growth factor β1 production and self-regulation of neutrophil inflammatory function in monosodium urate monohydrate crystal-induced inflammation in mice. Arthritis Rheum
Stocker BL, Jongkees SA, Win-Mason AL, Dangerfield EM, Withers SG, Timmer MS (2013) The ‘mirror-image’ postulate as a guide to the selection and evaluation of pyrrolidines as α-L-fucosidase inhibitors. Carbohydrate Res
Stocker BL, Timmer MS (2013) Chemical tools for studying the biological function of glycolipids. Chembiochem
Stocker BL, Timmer MS Trehalose diesters, lipoteichoic acids and α-GalCer: using chemistry to understand immunology. Carbohydrate Res
van Panhuys N, Camberis M, Yamada M, Tegoshi T, Arizono N, Le Gros G (2013) Mucosal trapping and degradation of Nippostrongylus brasiliensis occurs in the absence of STAT6. Parasitology
Weinkove R, Brooks CR, Carter JM, Hermans IF, Ronchese F (2013) Functional invariant natural killer T cell and CD1d axis in chronic lymphocytic leukemia: implications for immunotherapy. Haematologica
Weinkove R, Brooks C, Carter JM, Hermans IF, Ronchese F Efficient depletion of chronic lymphocytic leukemia B cells using serial rounds of immunomagnetic depletion. J Immunol Methods
Weinkove R, Clay J, Wood C (2013) Temperature management in haematology patients with febrile neutropenia: a practice survey. NZ Med J
Ataera H, Simkins HM, Hyde E, Yang J, Hermans IF, Petersen TR, Ronchese F (2013) The control of CD8+ T cell responses is preserved in perforin-deficient mice and released by depletion of CD4+ CD25+ regulatory T cells. J Leukoc Biol,
Benton MC, Lea RA, Macartney-Coxson D, Carless MA, Goring HH, Bellis C, Hanna M, Eccles D, Chambers GK, Curran JE, Harper JL, Blangero J, Griffiths LR (2013) Mapping eQTLs in the Norfolk Island genetic isolate identifies candidate genes for CVD risk traits. Am J Hum Genet
Kim S, Karasuyama H, Lopez AF, Ouyang W, Li X, Le Gros G, Min B (2013) IL-4 derived from non-T cells induces basophil- and IL-3-independent Th2 immune responses. Immune Netw
Kuhn S, Hyde EJ, Yang J, Rich FJ, Harper JL, Kirman JR, Ronchese F (2013) Increased numbers of monocyte-derived dendritic cells during successful tumor immunotherapy with immune-activating agents. J Immunol
Kuhn S, Ronchese F (2013) Monocyte-derived dendritic cells: Emerging players in the antitumor immune response. Oncoimmunology,
O’Sullivan D, Miller JH, Northcote PT, La Flamme AC (2013) Microtubule-stabilizing agents delay the onset of EAE through inhibition of migration. Immunol Cell Biol
Roohullah A, Moniwa A, Wood C, Humble M, Balm M, Carter J, Weinkove R (2013) Imipenem versus piperacillin/tazobactam for empiric treatment of febrile neutropenia in adults. Intern Med J
Shaw OM, Harper JL (2013) An efficient single prime protocol for the induction of antigen-induced airways inflammation. J Immunol Methods
Weinkove R, Brooks C, Carter J, Hermans I, Ronchese F (2013) Efficient depletion of chronic lymphocytic leukemia B cells using serial rounds of immunomagnetic depletion. J Immunol Methods
Weinkove R, Dickson M, Eliadou E, Stace NH, Goossens L, Ferguson P (2013) Fever and pancytopenia in a patient with Crohn's disease. Gut
2012
Ancelet LR, Aldwell FE, Rich FJ, Kirman JR (2012) Oral vaccination with lipid-formulated BCG induces a long-lived, multifunctional CD4+ T cell memory immune response. PLoS One
Ancelet L, Rich FJ, Delahunt B, Kirman JR (2012) Dissecting memory T cell responses to TB: Concerns using adoptive transfer into immunodeficient mice. Tuberculosis (Edinb)
Dickgreber N, Farrand KJ, van Panhuys N, Knight DA, McKee SJ, Chong ML, Miranda-Hernandez S, Baxter AG, Locksley RM, Le Gros G, Hermans IF (2012) Immature NKT cells pass through a stage of developmentally programmed innate IL-4 secretion. J Leukoc Biol
Herbst T, Esser J, Prati M, Kulagin M, Stettler R, Zaiss MM, Hewitson JP, Merky P, Verbeek JS, Bourquin C, Camberis M, Prout M, Maizels RM, Le Gros G, Harris NL (2012) Antibodies and IL-3 support helminth-induced basophil expansion. Proc Natl Acad Sci US
Hunn MK, Farrand KJ, Broadley KW, Weinkove R, Ferguson P, Miller RJ, Field CS, Petersen T, McConnell MJ, Hermans IF (2012) Vaccination with irradiated tumor cells pulsed with an adjuvant that stimulates NKT cells is an effective treatment for glioma. Clin Cancer Res
Kanakkanthara A, Rawson P, Northcote PT, Miller JH (2012) Acquired resistance to peloruside A and laulimalide is associated with downregulation of vimentin in human ovarian carcinoma cells. Pharm Res
La Flamme AC, Kharkrang M, Stone S, Mirmoeini S, Chuluundorj D, Kyle R (2012) Type II-activated murine macrophages produce IL-4. PLoS One
Lim SN, Kuhn S, Hyde E, Ronchese F (2012) Combined TLR stimulation with Pam3Cys and Poly I:C enhances Flt3-ligand dendritic cell activation for tumor immunotherapy. J Immunother
Liu X, Chia E, Shaw OM, Martin WJ, Harper JL (2012) Rapid CCL2 release by membrane stromal cells initiates MSU crystal-induced monocyte recruitment in a peritoneal model of gouty inflammation. Eur J Inflamm
Ma Z-I, Lim SN, Qin JS, Yang J, Enomoto N, Ruedl C, Ronchese F (2012) Murine CD4+ T cell responses are inhibited by cytotoxic T cell-mediated killing of dendritic cells and are restored by antigen transfer. PLoS One
Ma Z-I, Yang J, Qin JS, Richter A, Perret R, El-Deiry WS, Finnberg N, Ronchese F (2012) Inefficient boosting of antitumour CD8(+) T cells by dendritic-cell vaccines is rescued by restricting T-cell cytotoxic functions. Oncoimmunology
Parker S, La Flamme A, Salinas I (2012) The ontogeny of New Zealand groper (Polyprion oxygeneios) lymphoid organs and IgM. Dev Comp Immunol
Paterson DB, Poonam P, Bennett NC, Peszynski RI, Van Beekhuizen MJ, Jasperse ML, Herst PM (2012) Randomized intra-patient controlled trial of mepilex lite dressings versus aqueous cream in managing radiation-induced skin reactions post-mastectomy. J Cancer Sci Ther
Rawson P, Stockum C, Peng L, Manivannan B, Lehnert K, Ward HE, Berry SD, Davis SR, Snell RG, McLauchlan D, Jordan TW (2012) Metabolic proteomics of the liver and mammary gland during lactation. J Proteomics
Rich FJ, Kuhn S, Hyde EJ, Harper JL, Ronchese F, Kirman JR (2012) Induction of T cell responses and recruitment of an inflammatory dendritic cell subset following tumour immunotherapy with Mycobacterium smegmatis. Cancer Immunol Immunother
Robinson M, McConnell MJ, Le Gros G (2012) How epigenetic imprinting contributes to stabilizing the Th2 phenotype. Immunol Cell Biol
Sauvageau J, Foster AJ, Khan AA, Chee SH, Sims IM, Timmer MSM, Stocker BL (2012) Synthesis and biological activity of the LTA glycolipid anchor from Streptocossus sp. DSM 8747. Chembiochem
Smit AM, Strabala TJ, Peng L, Rawson P, Lloyd-Jones G, Jordan TW (2012) Proteomic phenotyping of Novosphingobium nitrogenifigens reveals a robust capacity for simultaneous nitrogen fixation, polyhydroxyalkanoate production, and resistance to reactive oxygen species. Appl Environ Microbiol
Williams JM, Young P, Pilcher J, Weatherall M, Miller JH, Beasley R, La Flamme AC (2012) Remote ischaemic preconditioning does not alter perioperative cytokine production in high-risk cardiac surgery. Heart Asia
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